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Safety information

This is a case study of Chinese made Sibutramine sold through the internet.

An article about sibutramine causing problems as mention above.


Sibutramine is contraindicated in patients with:

  • Psychiatric conditions as bulimia nervosa, anorexia nervosa, serious depression or pre-existing mania
  • Patients with a history of or a predisposition to drug or alcohol abuse
  • Hypersensitivity to the drug or any of the inactive ingredients
  • Patients below 18 and above 65 years of age[13]
  • Concomitant treatment with a MAO inhibitor, antidepressant or other centrally active drugs, particularly other anoretics
  • History of peripheral arterial disease
  • Hypertension that is not sufficiently controlled (e.g., >145/90 mmHg), caution in controlled hypertension
  • Existing pulmonary hypertension
  • Existing damage on heart valves, coronary heart disease, congestive heart failure, serious arrhythmias, previous myocardial infarction
  • A history of coronary artery disease (e.g., angina, history of myocardial infarction), congestive heart failure, tachycardia, peripheral arterial occlusive disease, arrhythmia or cerebrovascular disease (stroke or transient ischemic attack (TIA))[13]
  • Stroke or transient ischemic attack (TIA)
  • Hyperthyroidism (overactive thyroid gland)
  • Closed angle glaucoma
  • Seizure disorders
  • Enlargement of the prostate gland with urinary retention (relative contraindication)
  • Pheochromocytoma
  • Pregnant and lactating women (relative contraindication)


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